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In the reporting, patients with the highest BMIs (the most overweight) taking the highest dose of Trulicity (4.5 mg) experienced the most weight loss

These changes are largely the result of : - Rapid weight loss - Significant loss of muscle and connective tissue - Reduced structural support under the skin The Result : - Sagging facial skin - Sunken cheeks - Flattened or loose gluteal tissue - Accelerated appearance of aging This is not simply fat loss it is loss of tissue integrity, which becomes more noticeable when muscle mass is stripped away

Combating sarcopenia in geriatric rehabilitation patients: study protocol of the EMPOWER-GR observational cohort, sarcopenia awareness survey and randomised controlled feasibility trial

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Press Release, April 17, 2025